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Johannes Schnur

Characterizing the Leakage Mechanism of Thermoresponsive Liposomes using Time-Resolved Fluorescence

Principal investigator: Prof. Dr. Heiko Heerklotz

Institute of Pharmaceutical Sciences
Pharmaceutical Technology and Biopharmacy
Hermann-Herder-Str. 9, Raum 01.013
79104 Freiburg

Phone: +49 (0) 761-203-6336
johannes.schnur@pharmazie.uni-freiburg.de

Abstract

The major drawbacks in conventional tumor therapy are its high systemic toxicity and the low bioavailability of the drug molecules at the tumor site. Thermoresponsive Liposomes (TSLs) are capable of delivering the drug to the tumor site and release their content when triggered by mild hyperthermia (40—42°C).

While TSLs have been investigated since the 1970s, only little is known about their physicochemical properties, and how their components interact with blood proteins. We used Time-Resolved Fluorescence, Dynamic Light Scattering, Differential Scanning Calorimetry, and Isothermal Titration Calorimetry to systematically show the influence of various common constituents of TSLs on the phase- and release-behavior of TSLs. This will allow a more rational approach to design TSL formulations for new APIs.


Methods

Time-Resolved Fluorescence, Dynamic Light Scattering, Differential Scanning Calorimetry, Isothermal Titration Calorimetry